Molecular phylodynamic analysis of drug resistance transmissions in HIV-1 subtype B in Japan

To better understand epidemiology of HIV-1 subtype B transmission in Japan, we conducted a phylodynamic analysis using viral pol sequences of individuals who were newly diagnosed as HIV-1 seropositive. Cases newly diagnosed as HIV-1 infected between 2003 and 2009 were enrolled in the study. Protease...

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Bibliographic Details
Published in:Antiviral therapy 2013-01, Vol.18, p.A79-A79
Main Authors: Shiino, T, Sadamasu, K, Hattori, J, Nagashima, M, Iwatani, Y, Yokomaku, Y, Sugiura, W
Format: Article
Language:English
Subjects:
Human immunodeficiency virus 1
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Summary:To better understand epidemiology of HIV-1 subtype B transmission in Japan, we conducted a phylodynamic analysis using viral pol sequences of individuals who were newly diagnosed as HIV-1 seropositive. Cases newly diagnosed as HIV-1 infected between 2003 and 2009 were enrolled in the study. Protease reverse transcriptase (RT) sequences were collected and each region's subtype was determined using similarity plot analysis against subtype reference sequences. Samples classified as subtype B through whole protease- RT region (whole-B) were used for subsequent analysis. In Japan, HIV-1 subtype B transmits thorough MSM communities with over 200 distinct clusters. The geographical distribution during the network formation depends on the individual cases, suggesting that MSM communities in Japan have several subpopulations with a variety of relationships to local communities.
ISSN:1359-6535