Copper(I) Bromide Catalyzed Arylation of Cyclic Enamides and Naphthyl-1-acetamides Using Diaryliodonium Salts

Copper(I) bromide catalyzed direct C–H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields. A biologically active dihydro[a]­benzocarbazole scaffold was synthesized using the established protocol. The scope of t...

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Bibliographic Details
Published in:Journal of organic chemistry 2014-09, Vol.79 (17), p.7836-7843
Main Authors: Prakash, Muthuraj, Muthusamy, Subramaniam, Kesavan, Venkitasamy
Format: Article
Language:English
Subjects:
Acetamides - chemical synthesis
Acetamides - chemistry
Carbazoles - chemical synthesis
Carbazoles - chemistry
Catalysis
Copper - chemistry
Molecular Structure
Salts - chemistry
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Summary:Copper(I) bromide catalyzed direct C–H arylation of cyclic enamides was achieved using diaryliodonium salts in the absence of base/additive at ambient temperature with high yields. A biologically active dihydro[a]­benzocarbazole scaffold was synthesized using the established protocol. The scope of the current methodology was further extended for the synthesis of C4-, C7-aryl-substituted 1-naphthyl acetamides in good yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo501162s