A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides

A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for b...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-10, Vol.50 (78), p.11504-11506
Main Authors: Zhang, Yi-Wei, Li, Ze, Zhao, Qiang, Zhou, Ying-Lin, Liu, Hu-Wei, Zhang, Xin-Xiang
Format: Article
Language:English
Subjects:
Amines - chemistry
Animals
Chromium - chemistry
Coordination Complexes - chemistry
Glycopeptides - analysis
Glycopeptides - chemistry
Horseradish Peroxidase - chemistry
Horseradish Peroxidase - metabolism
Hydrophobic and Hydrophilic Interactions
Immunoglobulin G - chemistry
Immunoglobulin G - metabolism
Metals - chemistry
Mice
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Trypsin - metabolism
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Summary:A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc05179c