Predictive factors for a single successful cytapheresis session during the first mobilisation

Abstract To avoid repeated apheresis, the objective of this study was to analyse the predictive factors for a single successful cytapheresis during the first mobilisation. The pre-collection characteristics of 170 lymphoma and 95 myeloma patients were analysed. Among 60 lymphoma patients who had les...

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Bibliographic Details
Published in:Leukemia research 2014-09, Vol.38 (9), p.1020-1024
Main Authors: Gac, A.C, Parienti, J.J, Chantepie, S, Cheze, S, Johnson-Ansah, H, Benabed, K, Macro, M, Lefevre, V, Batho, A, Fruchart, C, Reman, O
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens, CD34 - blood
Cohort Studies
Cytapheresis - methods
Female
Hematology, Oncology and Palliative Medicine
Hematopoietic Stem Cell Mobilization - methods
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma
Lymphoma - blood
Lymphoma - diagnosis
Lymphoma - therapy
Male
Middle Aged
Multiple myeloma
Multiple Myeloma - blood
Multiple Myeloma - diagnosis
Multiple Myeloma - therapy
Plerixafor
Predictive Value of Tests
Prognosis
Single apheresis
Stem cell mobilisation
Transplantation Conditioning - methods
Transplantation, Autologous
Treatment Outcome
Young Adult
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Summary:Abstract To avoid repeated apheresis, the objective of this study was to analyse the predictive factors for a single successful cytapheresis during the first mobilisation. The pre-collection characteristics of 170 lymphoma and 95 myeloma patients were analysed. Among 60 lymphoma patients who had less than 30 CD34 cells/mm3 the day before the first apheresis, an increase in the CD34 cell count between Day −1 and Day 1 was predictive of first stem cell mobilisation success, with a sensitivity of 100% if the Day 1 was higher than 30/mm3 (10/60 patients). Success rate of obtaining an appropriate number of stem cells in one apheresis was 120 among 170 patients.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2014.05.001