Three-way and four-way junctions in DNA: a conformational viewpoint

DNA junctions are potential intermediates in various important genetic processes, including mutagenesis and recombination. The quantity of research carried out in this area is rapidly increasing. Examples of three-way and four-way junctions are now relatively well characterized and a few common prop...

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Bibliographic Details
Published in:Current opinion in structural biology 1996-06, Vol.6 (3), p.305-316
Main Authors: Altona, Cornelis, Pikkemaat, Jeroen A, Overmars, Franc JJ
Format: Article
Language:English
Subjects:
Base Sequence
DNA - chemistry
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Nucleic Acid Conformation
Recombination, Genetic
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Summary:DNA junctions are potential intermediates in various important genetic processes, including mutagenesis and recombination. The quantity of research carried out in this area is rapidly increasing. Examples of three-way and four-way junctions are now relatively well characterized and a few common properties have been recognized, of which the most important is the tendency of junctions to fold into one or more coaxially stacked helical conformations or cross-over structures.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(96)80048-0