Motor neurone disease

The diagnosis is a difficult clinical one, and rates of misdiagnosis are high outside motor neurone disease specialist centres. [...]it is recommended that if motor neurone disease is suspected, doctors refer urgently directly to someone with a special interest in the disease. Riluzole, a glutamate...

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Published in:BMJ (Online) 2014-07, Vol.349 (jul09 1), p.g4052-g4052
Main Authors: Nageshwaran, Saiji, Davies, Lucy Medina, Rafi, Imran, Radunović, Aleksandar
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Assisted suicide
Caregivers - psychology
Court decisions
EASILY MISSED?
Female
Hospice Care - psychology
Humans
Male
Motor Neuron Disease - psychology
Motor Neuron Disease - therapy
Palliative Care - psychology
Professional-Family Relations
Professional-Patient Relations
Right to die
Terminal Care - psychology
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container_issue jul09 1
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container_title BMJ (Online)
container_volume 349
creator Nageshwaran, Saiji
Davies, Lucy Medina
Rafi, Imran
Radunović, Aleksandar
description The diagnosis is a difficult clinical one, and rates of misdiagnosis are high outside motor neurone disease specialist centres. [...]it is recommended that if motor neurone disease is suspected, doctors refer urgently directly to someone with a special interest in the disease. Riluzole, a glutamate release antagonist, and non-invasive ventilation are currently the only treatments for motor neurone disease approved by the National Institute for Health and Care Excellence. 7 A Cochrane review (four randomised controlled trials involving 1477 patients) concluded that riluzole probably prolongs survival by two or three months 8 ; another Cochrane review (one randomised clinical trial, 41 patients) suggests that non-invasive ventilation prolongs survival (perhaps by many months) and improves or maintains quality of life in those with better bulbar function. 9 GPs have an important role as care coordinators once the diagnosis is made.
doi_str_mv 10.1136/bmj.g4052
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source JSTOR Archival Journals and Primary Sources Collection; BMJ_英国医学会期刊
subjects Amyotrophic lateral sclerosis
Assisted suicide
Caregivers - psychology
Court decisions
EASILY MISSED?
Female
Hospice Care - psychology
Humans
Male
Motor Neuron Disease - psychology
Motor Neuron Disease - therapy
Palliative Care - psychology
Professional-Family Relations
Professional-Patient Relations
Right to die
Terminal Care - psychology
title Motor neurone disease
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