Boswellia serrata has Beneficial Anti‐Inflammatory and Antioxidant Properties in a Model of Experimental Colitis

• Published in: Phytotherapy research 2014-09, Vol.28 (9), p.1392-1398
• Main Authors: Hartmann, Renata Minuzzo, Fillmann, Henrique Sarubbi, Morgan Martins, Maria Isabel, Meurer, Luise, Marroni, Norma Possa
• Format: Article
• Language: English
• Subjects: acetic acid; animal models; Animals; Anti-Inflammatory Agents - pharmacology; antioxidant activity; Antioxidants - pharmacology; anus; Boswellia - chemistry; Boswellia serrata; colitis; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - drug therapy; colon; Colon - pathology; Disease Models, Animal; inducible nitric oxide synthase; inflammation; intestinal mucosa; Lipid Peroxidation; Male; nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; oxidative stress; Plant Extracts - pharmacology; Rats; Rats, Wistar; thiobarbituric acid; Thiobarbituric Acid Reactive Substances - metabolism; thiobarbituric acid-reactive substances; ulcerative colitis
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.5142

Ulcerative colitis is an inflammatory disease that involves only the colon and rectum, being characterized by leukocyte infiltrate and superficial ulcers in the intestinal mucosa. To evaluate the anti‐inflammatory and antioxidant effects of extract from the Boswellia serrata plant in an experimental rat model of acute ulcerative colitis induced by the administration of acetic acid (AA). An extract of B. serrata (34.2 mg/kg/day) was administered by oral gavage for 2 days before and after the induction of colitis with 4 mL of 4% AA. The anal sphincter pressure in the colitis group showed a significant decrease compared to that of the control groups (p