3D Artificial Bones for Bone Repair Prepared by Computed Tomography-Guided Fused Deposition Modeling for Bone Repair

The medical community has expressed significant interest in the development of new types of artificial bones that mimic natural bones. In this study, computed tomography (CT)-guided fused deposition modeling (FDM) was employed to fabricate polycaprolactone (PCL)/hydroxyapatite (HA) and PCL 3D artifi...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2014-09, Vol.6 (17), p.14952-14963
Main Authors: Xu, Ning, Ye, Xiaojian, Wei, Daixu, Zhong, Jian, Chen, Yuyun, Xu, Guohua, He, Dannong
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Cell Line
Compressive Strength
Durapatite - chemistry
Elastic Modulus
Goats
Mice
Models, Theoretical
Nanoparticles - chemistry
Porosity
Prosthesis Implantation
Spectroscopy, Fourier Transform Infrared
Tissue Engineering - methods
Tomography, X-Ray Computed
Wound Healing
X-Ray Diffraction
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Summary:The medical community has expressed significant interest in the development of new types of artificial bones that mimic natural bones. In this study, computed tomography (CT)-guided fused deposition modeling (FDM) was employed to fabricate polycaprolactone (PCL)/hydroxyapatite (HA) and PCL 3D artificial bones to mimic natural goat femurs. The in vitro mechanical properties, in vitro cell biocompatibility, and in vivo performance of the artificial bones in a long load-bearing goat femur bone segmental defect model were studied. All of the results indicate that CT-guided FDM is a simple, convenient, relatively low-cost method that is suitable for fabricating natural bonelike artificial bones. Moreover, PCL/HA 3D artificial bones prepared by CT-guided FDM have more close mechanics to natural bone, good in vitro cell biocompatibility, biodegradation ability, and appropriate in vivo new bone formation ability. Therefore, PCL/HA 3D artificial bones could be potentially be of use in the treatment of patients with clinical bone defects.
ISSN:1944-8244
1944-8252
DOI:10.1021/am502716t