Efficient cobalt-catalyzed C-N cross-coupling reaction between benzamide and aryl iodide in water

A practical and efficient strategy for the N-arylation of benzamide catalysed by a Co(C2O4)·2H2O/dmeda system in water is reported. Under the optimized conditions, a wide variety of N-arylated products were obtained in good yields (up to 92%) using substituted aryl iodides.

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2014-10, Vol.12 (38), p.7478-7481
Main Authors: Tan, Bryan Yong-Hao, Teo, Yong-Chua
Format: Article
Language:English
Subjects:
Benzamides - chemistry
Benzene - chemistry
Carbon - chemistry
Catalysis
Cobalt - chemistry
Iodine - chemistry
Nitrogen - chemistry
Water - chemistry
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Description
Summary:A practical and efficient strategy for the N-arylation of benzamide catalysed by a Co(C2O4)·2H2O/dmeda system in water is reported. Under the optimized conditions, a wide variety of N-arylated products were obtained in good yields (up to 92%) using substituted aryl iodides.
ISSN:1477-0520
1477-0539
DOI:10.1039/c4ob01483a