The beneficial effect of acromegaly control on blood pressure values in normotensive patients

Summary Objective Control of acromegaly may ameliorate blood pressure (BP) in hypertensive (HT) patients. We evaluated the impact of acromegaly control on BP values of normotensive (NT) acromegalics. Design Retrospective cohort study. Patients Fifty‐eight naïve patients with acromegaly (39 F; age ra...

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Published in:Clinical endocrinology (Oxford) 2014-10, Vol.81 (4), p.573-581
Main Authors: Sardella, Chiara, Urbani, Claudio, Lombardi, Martina, Nuzzo, Alessandro, Manetti, Luca, Lupi, Isabella, Rossi, Giuseppe, Del Sarto, Simone, Scattina, Ilaria, Di Bello, Vitantonio, Martino, Enio, Bogazzi, Fausto
Format: Article
Language:English
Subjects:
Acromegaly - physiopathology
Adult
Aged
Biological and medical sciences
Blood Pressure - physiology
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Humans
Hypertension - physiopathology
Hypothalamus. Hypophysis. Epiphysis (diseases)
Male
Medical sciences
Middle Aged
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Retrospective Studies
Risk Factors
Vertebrates: endocrinology
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Summary:Summary Objective Control of acromegaly may ameliorate blood pressure (BP) in hypertensive (HT) patients. We evaluated the impact of acromegaly control on BP values of normotensive (NT) acromegalics. Design Retrospective cohort study. Patients Fifty‐eight naïve patients with acromegaly (39 F; age range, 30–69 years), including 28 NT and 30 HT subjects, participated in the study. Measurements Blood pressure was measured by clinical measurement and 24‐h ambulatory monitoring at diagnosis and after 24 months of medical therapy for acromegaly. Results Acromegaly was controlled by medical therapy in 15 NT and 17 HT patients at 24 months. In the NT group, systolic (SBP) or diastolic (DBP) BP significantly increased (all P 
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.12455