Decreased expression of the type I isozyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin

A spontaneous transformant derived from a mouse lung epithelial cell line exhibited decreased cAMP-dependent protein kinase (PKA) activity. DEAE column chromatography demonstrated that this was caused by specific loss of the type I PKA isozyme.

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Bibliographic Details
Published in:The Journal of biological chemistry 1990-01, Vol.264 (14), p.7814-7818
Main Authors: Lange-Carter, CA, Fossli, T, Jahnsen, T, Malkinson, A M
Format: Article
Language:English
Subjects:
cyclic AMP
protein kinase
Online Access:Get full text
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Description
Summary:A spontaneous transformant derived from a mouse lung epithelial cell line exhibited decreased cAMP-dependent protein kinase (PKA) activity. DEAE column chromatography demonstrated that this was caused by specific loss of the type I PKA isozyme.
ISSN:0021-9258