Development of Glassy Carbon Electrode Modified with Ruthenium Red-multiwalled Carbon Nanotubes for Simultaneous Determination of Epinephrine and Acetaminophen

• Published in: Analytical Sciences 2014/09/10, Vol.30(9), pp.911-918
• Main Authors: NADIKI, Hadi Hassani, NOROOZIFAR, Meissam, KHORASANI-MOTLAGH, Mozhgan
• Format: Article
• Language: English
• Subjects: acetaminophen; Acetaminophen - analysis; Analytical Chemistry; Calibration; Carbon - chemistry; carbon nanotubes; Chemistry; Electrochemical Techniques - instrumentation; Electrochemical Techniques - methods; Electrodes; epinephrine; Epinephrine - analysis; Limit of Detection; Nanotubes, Carbon - chemistry; Original Papers; Oxidation-Reduction; ruthenium red; Ruthenium Red - chemistry; Sensor; Surface Properties
• ISSN: 0910-6340; 1348-2246
• DOI: 10.2116/analsci.30.911

A glassy carbon electrode modified with ruthenium red and functionalized multi-walled carbon nanotube has been developed. The electrochemical response characteristics of the modified electrode toward epinephrine (EP) and acetaminophen (AC) was investigated by differential pulse voltammetry (DPV). Linear calibration plots were obtained over the range of 0.3 – 333.3 μM for both EP and AC with sensitivities of 0.221 and 0.174 μA μM−1 for EP and AC, respectively. The detection limits for EP and AC were 0.04 and 0.06 μM, respectively. The diffusion coefficients for the oxidation of EP and AC at the modified electrode were calculated as 2.74 ± 0.05 × 10−5 and 1.75 ± 0.07 × 10−5 cm2 s−1, respectively. The practical analytical utilities of the modified electrode were demonstrated by the determination of EP and AC in human urine and serum as well as AC tablet samples.