Effects of catechin-rich oil palm leaf extract on normal and hypertensive rats’ kidney and liver

►The effects of OPLE on the organs of normal & hypertensive animals. ► The safety of OPLE on normal and hypertensive animals. ► OPLE as a potential alternative abundant source of flavonoids and catechins. Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasod...

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Bibliographic Details
Published in:Food chemistry 2011-09, Vol.128 (2), p.433-441
Main Authors: Jaffri, Juliana M., Mohamed, Suhaila, Ahmad, Intan Natasya, Mustapha, Noordin M., Manap, Yazid A., Rohimi, Nordanial
Format: Article
Language:English
Subjects:
Antioxidant
Biological and medical sciences
Fat industries
Food industries
Fundamental and applied biological sciences. Psychology
Hypertension
Kidney
Liver
Oil palm leaf
Toxicity
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Summary:►The effects of OPLE on the organs of normal & hypertensive animals. ► The safety of OPLE on normal and hypertensive animals. ► OPLE as a potential alternative abundant source of flavonoids and catechins. Catechin-rich oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation, antioxidant and cardiovascular properties. This study evaluated the beneficial or toxic effects of OPLE on the liver and kidneys of normal and hypertensive rats. The OPLE (500mg/kg body weight) were administered orally to normal Wistar Kyoto rats, spontaneously hypertensive rats (SHR) and N-ω-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. The OPLE reduced hypertension in NO-deficient rats, but not in SHR. Hepatocytes or glomeruli injury and oxidative markers were high in hypertensive rats compared to normal rats, and they were reduced (p
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2011.03.050