The impact of bacteremia on the outcome of bone infections

• Published in: Médecine et maladies infectieuses 2014-08, Vol.44 (8), p.380-386
• Main Authors: Roger, P.-M., Cua, E., Courjon, J., Landraud, L., Carles, M., Bernard, E.
• Format: Article
• Language: English
• Subjects: Aged; Bacteremia; Bacteremia - complications; Bacterial diseases; Bacterial sepsis; Bactériémie; Biological and medical sciences; Bone Diseases - microbiology; Bone infection; Female; Human bacterial diseases; Humans; Infection ostéoarticulaire; Infectious diseases; Male; Medical sciences; Middle Aged; Outcome; Pronostic; Prospective Studies; Retrospective Studies; Staphylococcal infections, streptococcal infections, pneumococcal infections; Staphylococcus
• ISSN: 0399-077X; 1769-6690
• DOI: 10.1016/j.medmal.2014.07.013

We have used a medical database to analyze our activity since 2005. We observed a frequent association between bone and joint infection (BI) and bacteremia. Our aim was to characterize patients with BI and bacteremia, and focus on the outcome. Our database includes the prospective recording of 28 characteristics of all hospitalized patients, including diagnosis, comorbid conditions, microbiological data, therapy, and outcome. We selected patients presenting with BI in this database, from July 2005 to December 2012. Fever before blood culture was retrospectively documented from the patient's chart. Chronic BI was defined as a disease lasting more than 1month. An unfavorable outcome was defined by the need for intensive care or death. Six hundred and thirty-two patients presented with BI and 125 with bacteremia (19.8%). We used a stepwise logistic regression analysis and determined that bacteremia was associated with vertebral osteomyelitis, OR, 3.97, P