Free amino acids in stimulated and unstimulated whole saliva: advantages or disadvantages

Summary This study determines the mean concentrations of free amino acids in stimulated and unstimulated whole saliva in healthy young adults. Standardised salivary amino acids as a substitute for their counterpart in blood, searched for the source of free amino acids in saliva, the probable correla...

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Bibliographic Details
Published in:Journal of oral rehabilitation 2014-10, Vol.41 (10), p.759-767
Main Authors: Masoudi Rad, H., Rabiei, M., Sobhani, A., Sadegh Khanjani, M., Rahbar Taramsar, M., Kazemnezhad Leili, E.
Format: Article
Language:English
Subjects:
amino acids
Amino Acids - analysis
Chromatography, Liquid - methods
Citrulline - analysis
Cross-Sectional Studies
Dental Caries - metabolism
dental disease
Dentistry
Female
flow rate
Glutamine - analysis
Humans
Male
oral health
oral physiology
Ornithine - analysis
Phenylalanine - analysis
saliva
Saliva - chemistry
Serine - analysis
Threonine - analysis
Young Adult
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Summary:Summary This study determines the mean concentrations of free amino acids in stimulated and unstimulated whole saliva in healthy young adults. Standardised salivary amino acids as a substitute for their counterpart in blood, searched for the source of free amino acids in saliva, the probable correlation between particular amino acids with caries experience. Stimulated and unstimulated whole saliva were collected by the draining method in 31 dental students. Saliva was purified, and amino acids were separated by high‐performance liquid chromatography. DMFT scores were recorded, and the relation of amino acids to caries experience was explored by generalised linear model. Almost all amino acids had higher concentration in unstimulated whole saliva than in stimulated saliva. The normal range of amino acids (95% CI) and their natural logarithm were defined. There was a significant relationship between caries experience and threonine (P 
ISSN:0305-182X
1365-2842
DOI:10.1111/joor.12197