Factors affecting survival after resection of intrahepatic cholangiocarcinoma

Purpose This study aimed at assessing the prognostic factors of resection of intrahepatic cholangiocarcinoma (IHCC), which remain unclear. Methods Among 70 patients with IHCC, who were admitted to our hospital between 1998 and 2011, 45 (64 %) underwent resection and 25 had unresectable tumors. Univa...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2014-10, Vol.44 (10), p.1847-1854
Main Authors: Murakami, Sae, Ajiki, Tetsuo, Okazaki, Taro, Ueno, Kimihiko, Kido, Masahiro, Matsumoto, Ippei, Fukumoto, Takumi, Ku, Yonson
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bile Duct Neoplasms - mortality
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic - surgery
Biliary Tract Surgical Procedures - methods
Biliary Tract Surgical Procedures - mortality
Biomarkers, Tumor - blood
Cholangiocarcinoma - mortality
Cholangiocarcinoma - secondary
Cholangiocarcinoma - surgery
Female
Humans
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Prognosis
Retrospective Studies
Surgery
Surgical Oncology
Survival Rate
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Summary:Purpose This study aimed at assessing the prognostic factors of resection of intrahepatic cholangiocarcinoma (IHCC), which remain unclear. Methods Among 70 patients with IHCC, who were admitted to our hospital between 1998 and 2011, 45 (64 %) underwent resection and 25 had unresectable tumors. Univariate and multivariate analyses were conducted retrospectively to assess the factors influencing survival of the patients who underwent resection. Results The median survival times of the patients who underwent resection versus those who did not were 16 months versus 9 months, respectively ( P  5 mm) surgical margins. Conclusions R0/1 resection and a well-differentiated tumor were found to be independent prognostic factors for long-term survival after IHCC resection. If R0 resection was achieved, the width of the negative surgical margin did not affect the patterns and rates of recurrence.
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-013-0825-9