Metabolism of Pyriproxyfen. 2. Comparison of in Vivo Metabolism between Rats and Mice

The metabolic fate of pyriproxyfen [4-phenoxyphenyl (RS)-2-(2-pyridyloxy]propyl ether, Sumilarv) was examined in rats and mice given single oral doses of [pyridyl-2,6-14C]- or [phenoxyphenyl-14C]-pyriproxyfen at doses of 2 and 1000 mg/kg. The carbon-14 was excreted almost completely into urine and f...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1995-10, Vol.43 (10), p.2681-2686
Main Authors: Yoshino, Hiromi, Kaneko, Hideo, Nakatsuka, Iwao, Yamada, Hirohiko
Format: Article
Language:English
Subjects:
ANIMAL TISSUES
BIOCONVERSION
BIOLOGICAL DIFFERENCES
BIOTRANSFORMATION
DETOXIFICACION METABOLICA
DETOXIFICATION METABOLIQUE
DIFERENCIAS BIOLOGICAS
DIFFERENCE BIOLOGIQUE
EXCRECION
EXCREMENTS
EXCRETA
EXCRETION
METABOLIC DETOXIFICATION
METABOLISM
METABOLISME
METABOLISMO
MICE
PESTICIDE
PESTICIDES
PIRETRINAS SINTETICAS
PLAGUICIDAS
PYRETHRINE DE SYNTHESE
RAT
RATA
RATON
RATS
RESIDU
RESIDUES
RESIDUOS
SEX
SEXE
SEXO
SOURIS
SYNTHETIC PYRETHRINS
TEJIDOS ANIMALES
TISSU ANIMAL
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Summary:The metabolic fate of pyriproxyfen [4-phenoxyphenyl (RS)-2-(2-pyridyloxy]propyl ether, Sumilarv) was examined in rats and mice given single oral doses of [pyridyl-2,6-14C]- or [phenoxyphenyl-14C]-pyriproxyfen at doses of 2 and 1000 mg/kg. The carbon-14 was excreted almost completely into urine and feces within 7 days after dosing and fecal excretion of carbon-14 predominated in both animals. Excretion of carbon-14 into feces and urine was, respectively, 84-97% and 4-12% of the dose in rats and 64-91% and 9-38% in mice. Major metabolic reactions of pyriproxyfen were (1) hydroxylation at the 4-position of the terminal phenyl ring, (2) hydroxylation at the 2-position of the terminal phenyl ring, (3) hydroxylation at the 5-position of the pyridyl ring, (4) dephenylation, (6) cleavage of ether linkages, and (6) conjugation of the resultant phenols with sulfuric acid or glucuronic acid. Although there was generally no marked difference in the metabolic profile of pyriproxyfen between the two species, significant sex-related differences were found in metabolic reactions 1,3, and 6 in the rat but not in the mouse
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00058a024