Comparative activity of piperacillin/tazobactam against 5625 isolates from hospitalised patients

The comparative activities of piperacillin/tazobactam and other antibiotics against 5625 Gram-negative and Gram-positive bactena freshly isolated from hospitalized patients was examined. The percentage of Enterobacteriaceae susceptible to piperacillin/tazobactam, ceftazidime, imipenem and ciprofloxa...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1996, Vol.37 (2), p.285-293
Main Authors: Verbist, L., Verhaegen, J., Wounters, Ch, Vandenhoven, G.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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Summary:The comparative activities of piperacillin/tazobactam and other antibiotics against 5625 Gram-negative and Gram-positive bactena freshly isolated from hospitalized patients was examined. The percentage of Enterobacteriaceae susceptible to piperacillin/tazobactam, ceftazidime, imipenem and ciprofloxacin was very similar and varied from 81% to 84% in the Enterobacteriaceae with inducible type 1 β-lactamases and from 93 to 97% in the non-inducible organisms. Piperacillin/tazobactam was similar in activity to ceftazidime against Pseudomonas aeruginosa and more active than imipenem or ciprofloxacin. Piperacillin/tazobactam is more active than ceftazidime against Gram-positive bacteria (staphylococci, enterococci) and seems to be a promising antibiotic for nosocomial infections.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/37.2.285