Simulation of blood oxygenation in capillary membrane oxygenators using modified sulfite solution

Blood oxygenation is the main performance characteristic of capillary membrane oxygenators (CMOs). Handling of natural blood in in vitro investigations of CMOs is quite complex and time-consuming. Since the conventional blood analog fluids (e.g. water/glycerol) lack a substance with an affinity to c...

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Bibliographic Details
Published in:Biophysical chemistry 2014-12, Vol.195, p.8-15
Main Authors: Tabesh, Hadi, Amoabediny, Ghasem, Rasouli, Ali, Ramedani, Arash, Poorkhalil, Ali, Kashefi, Ali, Mottaghy, Khosrow
Format: Article
Language:English
Subjects:
Animals
Blood oxygenation
Capillary membrane oxygenator
Glycerol - chemistry
Hemoglobins - chemistry
Hemoglobins - metabolism
Oxygen - chemistry
Oxygen - metabolism
Oxygen transfer rate
Oxygenators, Membrane
Simulation
Solutions - chemistry
Sulfite solution
Sulfites - chemistry
Swine
Temperature
Viscosity
Water - chemistry
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Summary:Blood oxygenation is the main performance characteristic of capillary membrane oxygenators (CMOs). Handling of natural blood in in vitro investigations of CMOs is quite complex and time-consuming. Since the conventional blood analog fluids (e.g. water/glycerol) lack a substance with an affinity to capture oxygen comparable to hemoglobin's affinity, in this study a novel approach using modified sulfite solution is proposed to address this challenge. The solution comprises sodium sulfite as a component, simulating the role of hemoglobin in blood oxygenation. This approach is validated by OTR (oxygen transfer rate) measured using native porcine blood, in two types of commercially available CMOs. Consequently, the number of complicated natural blood investigations in the evolution procedure of newly developed oxygenators would considerably decrease. Moreover, the reassessing of failed devices, in clinics, would be performed more precisely using a modified sulfite solution than simple water/glycerol testing. [Display omitted]
ISSN:0301-4622
1873-4200
DOI:10.1016/j.bpc.2014.07.005