Immunoglobulins in neonatal sepsis: has the final word been said?

Summary Systemic infection is a major cause of mortality and morbidity among premature neonates. In this fragile population, the immaturity of the innate immune response relates inversely to gestational age and is one of the determinants of susceptibility to infections. Antibiotic therapy, even when...

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Bibliographic Details
Published in:Early human development 2014-09, Vol.90, p.S47-S49
Main Authors: Capasso, Letizia, Borrelli, Angela Carla, Ferrara, Teresa, Coppola, Clara, Cerullo, Julia, Izzo, Federica, Caiazza, Roberta, Lama, Silvia, Raimondi, Francesco
Format: Article
Language:English
Subjects:
Advanced Basic Science
Humans
IgM enriched immunoglobulins
Immunoglobulin M - immunology
Immunoglobulin M - therapeutic use
Immunoglobulins, Intravenous - therapeutic use
Immunotherapy
Infant, Newborn
Neonatal and Perinatal Medicine
Neonate
Sepsis
Sepsis - immunology
Sepsis - therapy
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Summary:Summary Systemic infection is a major cause of mortality and morbidity among premature neonates. In this fragile population, the immaturity of the innate immune response relates inversely to gestational age and is one of the determinants of susceptibility to infections. Antibiotic therapy, even when appropriately and timely instituted, may fail to prevent death or significant sequelae. The quest for additional strategies is still open; in this scenario, the supplementation with exogenous immunoglobulins represents an attractive additional strategy of defence. As current data are conflicting, we provide a critical appraisal with a focus on IgM enriched immunoglobulins preparations. © 2014 Elsevier Ireland Ltd. All rights reserved.
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(14)50013-8