Comparison of serum anti-Müllerian hormone levels in normal weight and overweight–obese adolescent patients with polycystic ovary syndrome

Abstract Objective To evaluate serum concentration of anti-Müllerian hormone (AMH) in adolescent patients with polycystic ovary syndrome (PCOS) with respect to body mass index (BMI), and to investigate the relationship with clinical, metabolic and hormonal parameters. Study design Fifty-eight adoles...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2014-09, Vol.180, p.46-50
Main Authors: Cengiz, Hüseyin, Ekin, Murat, Dagdeviren, Hediye, Yildiz, Şükrü, Kaya, Cihan, Kanawati, Ammar
Format: Article
Language:English
Subjects:
Adolescent
AMH
Anti-Mullerian Hormone - blood
Body Mass Index
Case-Control Studies
Female
Humans
Insulin Resistance
Insulin resistance (HOMA-IR)
Obese
Obesity - blood
Obesity - complications
Obstetrics and Gynecology
Ovarian Follicle - diagnostic imaging
Overweight
Overweight - blood
Overweight - complications
PCOS
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - diagnostic imaging
Prospective Studies
Ultrasonography
Young Adult
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Summary:Abstract Objective To evaluate serum concentration of anti-Müllerian hormone (AMH) in adolescent patients with polycystic ovary syndrome (PCOS) with respect to body mass index (BMI), and to investigate the relationship with clinical, metabolic and hormonal parameters. Study design Fifty-eight adolescent girls (29 normal weight and 29 overweight–obese) diagnosed with PCOS and 28 apparently healthy girls (controls) were enrolled in the study. BMI was calculated in all cases. Serum AMH, hormonal and metabolic parameters were compared between patients with PCOS (normal weight and overweight–obese) and controls. Results Serum AMH did not differ between patients with PCOS and controls ( p = 0.283), and no correlation was found between BMI and AMH. A significant positive correlation was found between 2-h plasma glucose on 75-g oral glucose tolerance test and AMH ( R = 0.364, p = 0.005). HOMA-IR index and insulin were significantly higher in overweight–obese patients with PCOS than in controls, but no significant difference was found between controls and normal-weight patients with PCOS. Conclusions AMH was not found to be a reliable predictor for the presence of PCOS, and serum AMH did not differ between obese and non-obese adolescent patients with PCOS.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2014.06.018