Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity

Highlights • A DP-4 peptide has been identified as a functional peptide of dermatopontin. • DP-4 promoted fibrinogen fibril formation, but did not affect fibrin formation. • DP-4-induced fibrinogen fibrils enhanced adhesion of HUVECs. • The cell adhesion was mediated by syndecan, αvβ3 and β1 integri...

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Bibliographic Details
Published in:Journal of dermatological science 2014-10, Vol.76 (1), p.34-43
Main Authors: Wu, Weimin, Okamoto, Osamu, Kato, Aiko, Matsuo, Noritaka, Kumai, Jun, Nomizu, Motoyoshi, Fujiwara, Sakuhei
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Cell Adhesion
Chondroitin Sulfate Proteoglycans - chemistry
Cytoskeleton - metabolism
Dermatology
Dermatopontin
DP-4 peptide
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - chemistry
Fibrin - chemistry
Fibrinogen
Fibrinogen - chemistry
Fibrinogen fibril
Human Umbilical Vein Endothelial Cells - cytology
Humans
Integrin alphaVbeta3 - metabolism
Molecular Sequence Data
Peptides - chemistry
Protein Interaction Mapping
Receptors, Vitronectin - metabolism
Syndecans - metabolism
Wound healing
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Summary:Highlights • A DP-4 peptide has been identified as a functional peptide of dermatopontin. • DP-4 promoted fibrinogen fibril formation, but did not affect fibrin formation. • DP-4-induced fibrinogen fibrils enhanced adhesion of HUVECs. • The cell adhesion was mediated by syndecan, αvβ3 and β1 integrins. • The DP-4-fibrinogen fibril might be used for a therapeutic purpose.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2014.07.002