Association between the epidermal growth factor gene polymorphism and endometriosis in women from Brazil

The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patie...

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Bibliographic Details
Published in:Genetics and molecular research 2014-09, Vol.13 (3), p.7239-7245
Main Authors: Oliveira, C B N, Falagan-Lotsch, P, Souza, M G, Santos, R P, Encinas, F, Teles, H, Lasmar, R B, Duarte, L B, Granjeiro, J M, Penna, I A
Format: Article
Language:English
Subjects:
Adult
Alleles
Brazil
Case-Control Studies
Endometriosis - genetics
Endometriosis - pathology
Epidermal Growth Factor - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Genetic
Risk Factors
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Summary:The aim of this study was to verify the association between the epidermal growth factor (EGF) +61 G/A polymorphism and the susceptibility to endometriosis using a case-control design study. The control group included fertile women without endometriosis and the case group included endometriosis patients. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to genotype the EGF +61 G/A polymorphism. Initially, a total of 184 individuals were analyzed. After matching by ethnicity, the control group was composed of 57 individuals, while the endometriosis group was composed of 57 patients. No statistically significant associations were observed between EGF +61 variants and the risk of endometriosis development (P>0.05). This is the first study correlating the EFG +61 G/A polymorphism and endometriosis in women from Brazil, and demonstrates that EFG +61 G/A is not associated with endometriosis susceptibility in Brazilian women.
ISSN:1676-5680
1676-5680
DOI:10.4238/2014.September.5.8