NOD2/CARD15 variants in Malaysian patients with sporadic colorectal cancer

Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental facto...

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Bibliographic Details
Published in:Genetics and molecular research 2014-03, Vol.13 (3), p.7079-7085
Main Authors: Lau, T P, Roslani, A C, Lian, L H, Lee, P C, Hilmi, I, Goh, K L, Chua, K H
Format: Article
Language:English
Subjects:
Alleles
Asian Continental Ancestry Group - genetics
Case-Control Studies
Colorectal Neoplasms - genetics
Gene Frequency
Genetic Association Studies
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Malaysia
Nod2 Signaling Adaptor Protein - genetics
Odds Ratio
Polymorphism, Single Nucleotide
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Summary:Colorectal cancer (CRC) is one of the most common types of cancer in both developed and developing countries. This disease is triggered by and progresses via the sequential accumulation of multiple genetic alterations. In addition, the interaction between low-penetrance genes and environmental factors can also increase the risk of developing CRC. Since inflammatory bowel diseases (IBDs) are one of the predisposing factors for CRC, IBD-related genes might, to a certain extent, be associated with cancer initiation. The nucleotide oligomerization domain 2/caspase activating recruitment domain 15 gene (NOD2/CARD15) is the most well-established gene to be associated with increased susceptibility to Crohn's disease. Thus, various studies have been performed to investigate the potential contribution of this gene to CRC risk. In this study, we aimed to determine the frequency of the Arg702Trp, Gly908Arg, 3020insC, Pro268Ser, and JW1 variants of NOD2/CARD15, and to investigate their association with CRC susceptibility. A total of 130 CRC patients and 212 healthy controls were recruited for this study. Subsequently, real-time polymerase chain reaction with TaqMan was performed for the genotyping of these NOD2/ CARD15 variants. None of the NOD2/CARD15 variants was statistically associated to CRC susceptibility in our Malaysian population. Our findings were remarkably similar to those of other Asian cohorts, which indicated that these NOD2/CARD15 variants exhibit genetic heterogeneity between Caucasian and Asian populations.
ISSN:1676-5680
1676-5680
DOI:10.4238/2014.March.19.3