The efficiency of apparent diffusion coefficient quantification in diagnosis of acute cholecystitis and in differentiation of cholecystitis from extrinsic benign gallbladder wall thickening

• Published in: Japanese journal of radiology 2014-09, Vol.32 (9), p.545-551
• Main Authors: Beyazal, Mehmet, Avcu, Serhat, Çeliker, Fatma Beyazal, Yavuz, Alpaslan, Toktaş, Osman
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Cholecystitis - diagnosis; Cholecystitis, Acute - diagnosis; Diagnosis, Differential; Diffusion Magnetic Resonance Imaging - methods; Echo-Planar Imaging - methods; Female; Gallbladder - pathology; Gallbladder Diseases - diagnosis; Humans; Image Processing, Computer-Assisted - methods; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Nuclear Medicine; Original Article; Prospective Studies; Radiology; Radiotherapy; ROC Curve; Sensitivity and Specificity
• ISSN: 1867-1071; 1867-108X
• DOI: 10.1007/s11604-014-0343-8

Purpose The aim of the current study was to assess the efficiency of the apparent diffusion coefficient (ADC) measurement in diagnosis of acute cholecystitis and in differentiation of cholecystitis from extrinsic benign gallbladder wall thickening. Methods Forty patients who were diagnosed to have acute cholecystitis by ultrasonographic examination were included in this study. The control group consisted of 18 patients without symptoms of gallstones and cholecystitis whose gallbladder walls were thickened due to cirrhotic ascites. Both groups were examined using diffusion weighted imaging, and the mean ADC values were compared using Student’s t -test. Results The diagnoses of the 40 patients were proven by histopathological examination. The mean ADC values of patients diagnosed with cholecystitis (1.68 ± 0.36 × 10 −3 mm 2 /s) were significantly lower than the mean ADC values of the control group (2.35 ± 0.24 × 10 −3 mm 2 /s) ( p