Increased incidence of herpes zoster in adult patients with peptic ulcer disease: a population-based cohort study

Peptic ulcer disease (PUD) has been linked to immunological dysfunctions and malnutrition—both are predictors of herpes zoster(HZ). We hypothesized that PUD patients might have a greater risk for developing HZ. Using the longitudinal National Health Insurance Research Database, we conducted a retros...

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Bibliographic Details
Published in:International journal of epidemiology 2013-12, Vol.42 (6), p.1873-1881
Main Authors: CHEN, Jen-Yin, CHENG, Tain-Junn, CHANG, Chia-Yu, LAN, Kuo-Mao, WENG, Shih-Feng, SHEU, Ming-Jen, TSENG, Su-Feng, HU, Miao-Lin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Cohort Studies
Female
Helicobacter Infections - epidemiology
Helicobacter pylori
Herpes Zoster - epidemiology
Human viral diseases
Humans
Incidence
Infectious diseases
Kaplan-Meier Estimate
Male
Medical sciences
Middle Aged
Miscellaneous
Peptic Ulcer - epidemiology
Proportional Hazards Models
Public health. Hygiene
Public health. Hygiene-occupational medicine
Retrospective Studies
Risk Factors
Taiwan - epidemiology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Young Adult
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Summary:Peptic ulcer disease (PUD) has been linked to immunological dysfunctions and malnutrition—both are predictors of herpes zoster(HZ). We hypothesized that PUD patients might have a greater risk for developing HZ. Using the longitudinal National Health Insurance Research Database, we conducted a retrospective population-based cohort study to evaluate the incidence of HZ in adult PUD patients and controls matched by age and gender. Kaplan-Meier analysis and Cox regression were conducted to compare differences in the development of HZ. The effects of comorbidities on the risk of HZ and the associations between different risk factors of PUD and HZ were assessed by subgroup analyses. We identified 41 229 adults PUD patients and 41 229 controls. Over an 8-year follow-up, the cumulative incidence of HZ in PUD patients(11.76/1000 person-years) was significantly higher than controls(6.56/1000 person-years) (P
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyt213