Loading…
Nodal distribution, stage migration due to diameter measurement and the prognostic significance of metastasis volume in melanoma sentinel lymph nodes: a validation study
To validate metastasis location, maximum metastasis diameter (MMD) measurement induced stage migration and the prognostic significance of total metastatic volume (TMV) in melanoma sentinel lymph nodes (SLNs). A new 227 patient SLN cohort examined by complete step sectioning (250 μm) was tested for T...
Saved in:
Published in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2014-10, Vol.122 (10), p.968-975 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | To validate metastasis location, maximum metastasis diameter (MMD) measurement induced stage migration and the prognostic significance of total metastatic volume (TMV) in melanoma sentinel lymph nodes (SLNs). A new 227 patient SLN cohort examined by complete step sectioning (250 μm) was tested for TMV and MMD prognostic significance; metastasis location by three different three‐level protocols (Central vs Peripheral vs Global); and potential treatment changing down‐staging by two restricted five‐level protocols [Reduced Central (250 μm) vs Reduced Even (500 μm) sections]. Both TMV and MMD independently predicted recurrence (TMV, hazard ratio (HR): 1.21; 95% confidence interval (CI) 1.07–1.37; p = 0.003; and MMD, HR: 1.46; 95% CI 1.08–1.98, p = 0.02) and melanoma‐specific death (TMV, HR: 1.30; 95% CI 1.11–1.51; p = 0.001; and MMD, HR: 1.82; 95% CI 1.25–2.66, p = 0.002). The Central, Peripheral and Global protocols detected 72%, 76% and 83% of metastases found by complete step sectioning. Based on MMD, using the Reduced Central or Reduced Even protocols, potential treatment changing down‐staging occurred in 20 (20%) or 13 (13%) of SLN‐positive patients. This validation study establishes that: (i) metastases are globally located in melanoma SLNs; (ii) MMD but not TMV leads to uni‐directional stage migration; and (iii) TMV analysis is of prognostic significance. |
---|---|
ISSN: | 0903-4641 1600-0463 |
DOI: | 10.1111/apm.12240 |