Two New Anxiolytic Phenanthrenes Found in the Medullae of Juncus effusus

Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxio...

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Bibliographic Details
Published in:Natural product communications 2014-08, Vol.9 (8), p.1177-1178
Main Authors: Wang, Yang, Li, Gui-Yun, Fu, Qian, Hao, Tai-Sen, Huang, Jian-Mei, Zhai, Hai-Feng
Format: Article
Language:English
Subjects:
Animals
Anti-Anxiety Agents - administration & dosage
Anti-Anxiety Agents - chemistry
Anti-Anxiety Agents - isolation & purification
Anxiety - drug therapy
Humans
Magnoliopsida - chemistry
Male
Mice
Phenanthrenes - administration & dosage
Phenanthrenes - chemistry
Phenanthrenes - isolation & purification
Plant Extracts - administration & dosage
Plant Extracts - chemistry
Plant Extracts - isolation & purification
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Summary:Six phenanthrenes, 2-methoxy-7-hydroxy-1-methyl-5-vinyl phenanthrene (1), juncusin (2), dehydroeffusol (3), juncusol (4), effusol (5), and dehydroeffusal (6), were isolated from the medullae of Juncus effusus L. Compounds 1 and 2 were identified as being new structures, and both of them showed anxiolytic activity at dosages of 10 and 2.5 mg/kg, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1400900830