Synchronous lobular carcinoma in situ and invasive lobular cancer: Marker or precursor for invasive lobular carcinoma

Abstract Aim Lobular carcinoma in situ (LCIS) is a known risk factor for invasive breast carcinoma, but there is increasing data indicating a possible precursor relationship. This study investigates the incidence of lobular carcinoma in situ that occurs with invasive lobular carcinoma (ILC). Methods...

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Bibliographic Details
Published in:European journal of surgical oncology 2014-10, Vol.40 (10), p.1245-1249
Main Authors: Wallace, A.S, Xiang, D, Hockman, L, Arya, M, Jeffress, J, Wang, Z, Dale, P.S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Breast
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Carcinoma in Situ - pathology
Carcinoma in Situ - surgery
Carcinoma, Lobular - pathology
Carcinoma, Lobular - surgery
Cohort Studies
Disease Progression
Female
Hematology, Oncology and Palliative Medicine
Humans
Lobular carcinoma
Lobular carcinoma in situ
Mastectomy
Mastectomy, Segmental
Middle Aged
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Outcome
Precursor
Retrospective Studies
Surgery
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Summary:Abstract Aim Lobular carcinoma in situ (LCIS) is a known risk factor for invasive breast carcinoma, but there is increasing data indicating a possible precursor relationship. This study investigates the incidence of lobular carcinoma in situ that occurs with invasive lobular carcinoma (ILC). Methods Women diagnosed with ILC or LCIS from 2000 to 2010 were retrospectively identified and reviewed after institutional review board approval. This group was divided into two cohorts: ILC alone, and LCIS and ILC (ILC/LCIS). Patient demographics, disease characteristics, and treatment modalities were captured. p  
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2014.04.007