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In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells
Ether lipid analogues of platelet-activating factor (1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) possess a wide range of biological activities, including inhibition of neoplastic cell growth in vitro and in vivo. This activity is believed to be membrane mediated. Three different ether lipid an...
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| Published in: | Cancer research (Chicago, Ill.) Ill.), 1988-04, Vol.48 (7), p.1788-1791 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1791 |
| container_issue | 7 |
| container_start_page | 1788 |
| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 48 |
| creator | NOSEDA, A BERENS, M. E GAINES WHITE, J MODEST, E. J |
| description | Ether lipid analogues of platelet-activating factor (1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) possess a wide range of biological activities, including inhibition of neoplastic cell growth in vitro and in vivo. This activity is believed to be membrane mediated. Three different ether lipid analogues, 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine, 1-thiohexadecyl-2-ethyl-rac-glycero-3-phosphocholine, and 4-amino-methyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine , were combined with three DNA-interactive drugs, Adriamycin, 4-hydroperoxycyclophosphamide, and cisplatin, in the expectation that combinations of drugs with different mechanisms of action might show enhanced antitumor activity. The in vitro antiproliferative activity of the combinations was measured with a semisoft agarose clonogenic assay of an ovarian adenocarcinoma cell line. Various permutations of drug combinations were studied. Isobologram analyses and different treatment schedules were performed. Enhanced antiproliferative activity was found with combinations of ether lipids with DNA-interactive drugs in comparison with single agents. Statistical evaluation of the data indicated that the increase in activity was due to an additivity phenomenon. Neither synergism nor antagonism was found. |
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E ; GAINES WHITE, J ; MODEST, E. J</creator><creatorcontrib>NOSEDA, A ; BERENS, M. E ; GAINES WHITE, J ; MODEST, E. J</creatorcontrib><description>Ether lipid analogues of platelet-activating factor (1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) possess a wide range of biological activities, including inhibition of neoplastic cell growth in vitro and in vivo. This activity is believed to be membrane mediated. Three different ether lipid analogues, 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine, 1-thiohexadecyl-2-ethyl-rac-glycero-3-phosphocholine, and 4-amino-methyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine , were combined with three DNA-interactive drugs, Adriamycin, 4-hydroperoxycyclophosphamide, and cisplatin, in the expectation that combinations of drugs with different mechanisms of action might show enhanced antitumor activity. The in vitro antiproliferative activity of the combinations was measured with a semisoft agarose clonogenic assay of an ovarian adenocarcinoma cell line. Various permutations of drug combinations were studied. Isobologram analyses and different treatment schedules were performed. Enhanced antiproliferative activity was found with combinations of ether lipids with DNA-interactive drugs in comparison with single agents. Statistical evaluation of the data indicated that the increase in activity was due to an additivity phenomenon. Neither synergism nor antagonism was found.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 3349458</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenocarcinoma ; Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols ; Biological and medical sciences ; Cell Division - drug effects ; Cell Survival - drug effects ; Cisplatin - administration & dosage ; Cyclophosphamide - administration & dosage ; Cyclophosphamide - analogs & derivatives ; Doxorubicin - administration & dosage ; Female ; General aspects ; In Vitro Techniques ; Medical sciences ; Ovarian Neoplasms ; Pharmacology. Drug treatments ; Phospholipid Ethers - pharmacology ; Piperidines - pharmacology ; Tumor Cells, Cultured</subject><ispartof>Cancer research (Chicago, Ill.), 1988-04, Vol.48 (7), p.1788-1791</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7699458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3349458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NOSEDA, A</creatorcontrib><creatorcontrib>BERENS, M. E</creatorcontrib><creatorcontrib>GAINES WHITE, J</creatorcontrib><creatorcontrib>MODEST, E. J</creatorcontrib><title>In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Ether lipid analogues of platelet-activating factor (1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) possess a wide range of biological activities, including inhibition of neoplastic cell growth in vitro and in vivo. This activity is believed to be membrane mediated. Three different ether lipid analogues, 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine, 1-thiohexadecyl-2-ethyl-rac-glycero-3-phosphocholine, and 4-amino-methyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine , were combined with three DNA-interactive drugs, Adriamycin, 4-hydroperoxycyclophosphamide, and cisplatin, in the expectation that combinations of drugs with different mechanisms of action might show enhanced antitumor activity. The in vitro antiproliferative activity of the combinations was measured with a semisoft agarose clonogenic assay of an ovarian adenocarcinoma cell line. Various permutations of drug combinations were studied. Isobologram analyses and different treatment schedules were performed. Enhanced antiproliferative activity was found with combinations of ether lipids with DNA-interactive drugs in comparison with single agents. Statistical evaluation of the data indicated that the increase in activity was due to an additivity phenomenon. Neither synergism nor antagonism was found.</description><subject>Adenocarcinoma</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cisplatin - administration & dosage</subject><subject>Cyclophosphamide - administration & dosage</subject><subject>Cyclophosphamide - analogs & derivatives</subject><subject>Doxorubicin - administration & dosage</subject><subject>Female</subject><subject>General aspects</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Ovarian Neoplasms</subject><subject>Pharmacology. Drug treatments</subject><subject>Phospholipid Ethers - pharmacology</subject><subject>Piperidines - pharmacology</subject><subject>Tumor Cells, Cultured</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNo9UMtOwzAQtBColMInIPmAuEXyI06cY1VelSq4wDmyY7s1SuxiO5U48ue4NOK0Ozuzo9k9A3PMKC_qsmTnYI4Q4gUra3IJrmL8zJBhxGZgRmnZlIzPwc_awYNNwUPhkt0H31ujg0j2oKHocrHpG3oDOz9I6_Lcu3jEOu10gL3dW5U3Re-3o465U_DhdVlYl7JJd3LZapcytRXWxQR34yAcTOPgA-x038drcGFEH_XNVBfg4-nxffVSbN6e16vlptgRXKZCN4pKaZhSgkvMVS0pkpgwTnhFOCWNVBQZxXVluloZTlQmkZbKYMUk0nQB7k---civHDa1g43HBMJpP8YWs6rEDaFZeDsJRzlo1e6DHUT4bqefZf5u4kXsRG-CcJ2N_7K6av5kv8tAeVc</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>NOSEDA, A</creator><creator>BERENS, M. E</creator><creator>GAINES WHITE, J</creator><creator>MODEST, E. J</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TM</scope></search><sort><creationdate>19880401</creationdate><title>In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells</title><author>NOSEDA, A ; BERENS, M. E ; GAINES WHITE, J ; MODEST, E. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h214t-e9d3bbf5dda8b18d7b30b125828628329bd30fd8e6fc7df82d1250ebdf1d5b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adenocarcinoma</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cisplatin - administration & dosage</topic><topic>Cyclophosphamide - administration & dosage</topic><topic>Cyclophosphamide - analogs & derivatives</topic><topic>Doxorubicin - administration & dosage</topic><topic>Female</topic><topic>General aspects</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Ovarian Neoplasms</topic><topic>Pharmacology. Drug treatments</topic><topic>Phospholipid Ethers - pharmacology</topic><topic>Piperidines - pharmacology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOSEDA, A</creatorcontrib><creatorcontrib>BERENS, M. E</creatorcontrib><creatorcontrib>GAINES WHITE, J</creatorcontrib><creatorcontrib>MODEST, E. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Nucleic Acids Abstracts</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOSEDA, A</au><au>BERENS, M. E</au><au>GAINES WHITE, J</au><au>MODEST, E. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>48</volume><issue>7</issue><spage>1788</spage><epage>1791</epage><pages>1788-1791</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>Ether lipid analogues of platelet-activating factor (1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine) possess a wide range of biological activities, including inhibition of neoplastic cell growth in vitro and in vivo. This activity is believed to be membrane mediated. Three different ether lipid analogues, 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine, 1-thiohexadecyl-2-ethyl-rac-glycero-3-phosphocholine, and 4-amino-methyl-1-[2,3-(di-n-decyloxy)-n-propyl]-4-phenylpiperidine , were combined with three DNA-interactive drugs, Adriamycin, 4-hydroperoxycyclophosphamide, and cisplatin, in the expectation that combinations of drugs with different mechanisms of action might show enhanced antitumor activity. The in vitro antiproliferative activity of the combinations was measured with a semisoft agarose clonogenic assay of an ovarian adenocarcinoma cell line. Various permutations of drug combinations were studied. Isobologram analyses and different treatment schedules were performed. Enhanced antiproliferative activity was found with combinations of ether lipids with DNA-interactive drugs in comparison with single agents. Statistical evaluation of the data indicated that the increase in activity was due to an additivity phenomenon. Neither synergism nor antagonism was found.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>3349458</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 1988-04, Vol.48 (7), p.1788-1791 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Adenocarcinoma Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Combined Chemotherapy Protocols Biological and medical sciences Cell Division - drug effects Cell Survival - drug effects Cisplatin - administration & dosage Cyclophosphamide - administration & dosage Cyclophosphamide - analogs & derivatives Doxorubicin - administration & dosage Female General aspects In Vitro Techniques Medical sciences Ovarian Neoplasms Pharmacology. Drug treatments Phospholipid Ethers - pharmacology Piperidines - pharmacology Tumor Cells, Cultured |
| title | In vitro antiproliferative activity of combinations of ether lipid analogues and DNA-interactive agents against human tumor cells |
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