Mesoderm induction in zebrafish

Mesoderm formation and its dorsoventral specification are essential processes in vertebrate early development. The mesoderm produces many types of tissues such as notochord, muscle, bone and blood cells, arranged in the correct positions along the dorsoventral axis. The mechanisms underlying these p...

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Bibliographic Details
Published in:Nature (London) 1996-09, Vol.383 (6596), p.131-132
Main Authors: Mizuno, Toshiro, Yamaha, Etsuro, Wakahara, Masami, Kuroiwa, Atsushi, Takeda, Hiroyuki
Format: Article
Language:English
Subjects:
Danio rerio
Humanities and Social Sciences
multidisciplinary
Science
Science (multidisciplinary)
scientific-correspondence
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Summary:Mesoderm formation and its dorsoventral specification are essential processes in vertebrate early development. The mesoderm produces many types of tissues such as notochord, muscle, bone and blood cells, arranged in the correct positions along the dorsoventral axis. The mechanisms underlying these processes are best understood in the amphibian Xenopus, whereas little is known about this process in other vertebrates. In amphibia, the mesoderm differentiates in the equatorial region of the blastula-stage embryo through inductive interactions with vegetal blastomeres; the dorsoventral polarity of the mesoderm also depends on signals from dorsovegetal blastomeres. Are similar mechanisms involved in the development of teleost fish? Which tissues are responsible for mesoderm induction in the teleosts? We have addressed these questions using zebrafish embryos.
ISSN:0028-0836
1476-4687
DOI:10.1038/383131a0