Tissue Characterization of Progressive Cardiac Allograft Vasculopathy in Patients With Everolimus Therapy Compared With Donor-Transmitted Atherosclerosis Assessed Using Serial Intravascular Imaging: A Case Report

Abstract Using serial intravascular ultrasound (IVUS), integrated-backscatter IVUS, and optical coherence tomography, we observed rapidly progressive cardiac allograft vasculopathy (CAV) and donor-transmitted plaque in the left anterior descending artery. Late-phase everolimus-resistant CAV had a ra...

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Bibliographic Details
Published in:Transplantation proceedings 2014-09, Vol.46 (7), p.2456-2461
Main Authors: Watanabe, T, Kotani, J, Murata, Y, Seguchi, O, Yanase, M, Nakatani, T
Format: Article
Language:English
Subjects:
Allografts
Coronary Angiography
Coronary Artery Disease - etiology
Coronary Artery Disease - pathology
Coronary Vessels - diagnostic imaging
Disease Progression
Drug Resistance
Everolimus
Heart Transplantation
Humans
Immunosuppressive Agents - adverse effects
Male
Middle Aged
Plaque, Atherosclerotic - pathology
Sirolimus - adverse effects
Sirolimus - analogs & derivatives
Surgery
Ultrasonography
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Summary:Abstract Using serial intravascular ultrasound (IVUS), integrated-backscatter IVUS, and optical coherence tomography, we observed rapidly progressive cardiac allograft vasculopathy (CAV) and donor-transmitted plaque in the left anterior descending artery. Late-phase everolimus-resistant CAV had a rapidly progressive course (maximal intimal thickness [MIT] increased by 0.5 mm between years 3 and 4 after cardiac transplantation, from MIT growth 
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2014.03.014