Nitric Oxide Regulation of Tissue Free Radical Injury

We have presented evidence from a broad range of chemical, cell biological, and in vivo studies showing that .NO can mediate tissue-protective reactions during oxidant stress, as well as toxic and tissue prooxidant effects. One predominant factor that has been identified which influences .NO being p...

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Bibliographic Details
Published in:Chemical research in toxicology 1996-07, Vol.9 (5), p.809-820
Main Authors: Rubbo, Homero, Darley-Usmar, Victor, Freeman, Bruce A
Format: Article
Language:English
Subjects:
Animals
Antioxidants - chemistry
Antioxidants - pharmacology
Free Radicals - adverse effects
Free Radicals - chemistry
Humans
Nitric Oxide - metabolism
Nitric Oxide - physiology
Oxygen Consumption - drug effects
Oxygen Consumption - physiology
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Summary:We have presented evidence from a broad range of chemical, cell biological, and in vivo studies showing that .NO can mediate tissue-protective reactions during oxidant stress, as well as toxic and tissue prooxidant effects. One predominant factor that has been identified which influences .NO being protective versus toxic is the relative rates of production and concentrations of .NO and the more "traditional" family of reactive oxygen species, including O2.-, H2O2, .OH, LO., LOO., and high valency complexes of iron. Also, since so many anti-neutrophil actions of .NO have been described, it is likely that .NO will serve a protective role in acute inflammatory reactions. One issue is certain--many new truths remain to be revealed, as we continue to develop our understanding of the toxicology of reactive oxygen- and nitrogen-containing species.
ISSN:0893-228X
1520-5010
DOI:10.1021/tx960037q