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Clinical Correlates of Infarct Shape and Volume in Lacunar Strokes: The Secondary Prevention of Small Subcortical Strokes Trial

BACKGROUND AND PURPOSE—Infarct size and location are thought to correlate with different mechanisms of lacunar infarcts. We examined the relationship between the size and shape of lacunar infarcts and vascular risk factors and outcomes. METHODS—We studied 1679 participants in the Secondary Preventio...

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Bibliographic Details
Published in:Stroke (1970) 2014-10, Vol.45 (10), p.2952-2958
Main Authors: Asdaghi, Negar, Pearce, Lesly A, Nakajima, Makoto, Field, Thalia S, Bazan, Carlos, Cermeno, Franco, McClure, Leslie A, Anderson, David C, Hart, Robert G, Benavente, Oscar R
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Language:English
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Summary:BACKGROUND AND PURPOSE—Infarct size and location are thought to correlate with different mechanisms of lacunar infarcts. We examined the relationship between the size and shape of lacunar infarcts and vascular risk factors and outcomes. METHODS—We studied 1679 participants in the Secondary Prevention of Small Subcortical Stroke trial with a lacunar infarct visualized on diffusion-weighted imaging. Infarct volume was measured planimetrically, and shape was classified based on visual analysis after 3-dimensional reconstruction of axial MRI slices. RESULTS—Infarct shape was ovoid/spheroid in 63%, slab in 12%, stick in 7%, and multicomponent in 17%. Median infarct volume was smallest in ovoid/spheroid relative to other shapes0.46, 0.65, 0.54, and 0.90 mL, respectively (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.114.005211