Antimicrobial drug resistance among clinically relevant bacterial isolates in sub-Saharan Africa: a systematic review

Little is known about the prevalence of antimicrobial resistance (AMR) amongst bacterial pathogens in sub-Saharan Africa (sSA), despite calls for continent-wide surveillance to inform empirical treatment guidelines. We searched PubMed and additional databases for susceptibility data of key pathogens...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2014-09, Vol.69 (9), p.2337-2353
Main Authors: Leopold, Stije J, van Leth, Frank, Tarekegn, Hayalnesh, Schultsz, Constance
Format: Article
Language:English
Subjects:
Africa South of the Sahara - epidemiology
Anti-Bacterial Agents - pharmacology
Bacteria - classification
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial Infections - epidemiology
Bacterial Infections - microbiology
Drug resistance
Drug Resistance, Bacterial
Humans
Medical treatment
Nosocomial infections
Prevalence
Salmonella
Surveillance
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Summary:Little is known about the prevalence of antimicrobial resistance (AMR) amongst bacterial pathogens in sub-Saharan Africa (sSA), despite calls for continent-wide surveillance to inform empirical treatment guidelines. We searched PubMed and additional databases for susceptibility data of key pathogens for surveillance, published between 1990 and 2013. Extracted data were standardized to a prevalence of resistance in populations of isolates and reported by clinical syndrome, microorganism, relevant antimicrobial drugs and region. We identified 2005 publications, of which 190 were analysed. Studies predominantly originated from east sSA (61%), were hospital based (60%), were from an urban setting (73%) and reported on isolates from patients with a febrile illness (42%). Quality procedures for susceptibility testing were described in
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dku176