Angioedema Related to Angiotensin Inhibitors

Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angioten...

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Bibliographic Details
Published in:Journal of pharmacy practice 2014-10, Vol.27 (5), p.461-465
Main Authors: Knecht, Stephanie E., Dunn, Steven P., Macaulay, Tracy E.
Format: Article
Language:English
Subjects:
Angioedema - chemically induced
Angioedema - immunology
Angioedema - physiopathology
Angiotensin Receptor Antagonists - adverse effects
Angiotensin Receptor Antagonists - therapeutic use
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Bradykinin - drug effects
Humans
Hypertension - drug therapy
Incidence
Renin-Angiotensin System - physiology
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Summary:Angiotensin inhibitors have been extensively evaluated in clinical trials and have demonstrated significant reductions in morbidity and mortality following myocardial infarction and stroke, as well as in patients with heart failure or who are at risk of cardiovascular disease. Further, both angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are frequently prescribed for the treatment of hypertension and to preserve renal function in patients with diabetes mellitus and chronic kidney disease. Angioedema is a known, but rare, adverse effect of ACEIs and ARBs. Therefore, it is important for clinicians to have a thorough understanding of risks and benefits of prescribing these medications, particularly in patients with a history of angioedema. This review describes the literature evaluating the incidence and cross-reactivity of angioedema with ACEIs and ARBs in order to provide guidance for clinical decision making.
ISSN:0897-1900
1531-1937
DOI:10.1177/0897190014546101