Risk factors for retropharyngeal cellulitis in Kawasaki disease

• Published in: Auris, nasus, larynx nasus, larynx, 2014-10, Vol.41 (5), p.455-458
• Main Authors: Tona, Risa, Shinohara, Shogo, Fujiwara, Keizo, Kikuchi, Masahiro, Kanazawa, Yuji, Kishimoto, Ippei, Harada, Hiroyuki, Naito, Yasushi
• Format: Article
• Language: English
• Subjects: Age Factors; Cellulitis - diagnostic imaging; Cellulitis - etiology; Child; Child, Preschool; Edema - diagnostic imaging; Edema - etiology; Female; Humans; Infant; Kawasaki disease; Lymphatic Diseases - etiology; Male; Mucocutaneous Lymph Node Syndrome - complications; Mucocutaneous Lymph Node Syndrome - diagnostic imaging; Mucocutaneous lymph-node syndrome; Neck; Otolaryngology; Pharyngeal Diseases - diagnostic imaging; Pharyngeal Diseases - etiology; Pharynx; Retropharyngeal cellulitis; Retrospective Studies; Risk Factors; Tomography, X-Ray Computed
• ISSN: 0385-8146; 1879-1476
• DOI: 10.1016/j.anl.2014.05.017

Abstract Objective Kawasaki disease (KD) is an acute multisystemic vasculitis of unknown etiology that occurs in infants and children. Retropharyngeal cellulitis has been reported as a rare manifestation of KD. This study investigated the frequency and characteristics of patients with KD manifesting as retropharyngeal soft-tissue swelling. Methods We retrospectively reviewed 277 patients, with a mean age of 1 year and an age range of 7 months to 12 years, in whom KD had been diagnosed between 2005 and 2011. Results In 10 patients (3.6%), contrast-enhanced computed tomography (CECT) showed low-density lesions without ring enhancement in the retropharyngeal spaces. These patients presented initially with fever and cervical lymphadenopathy, and were initially treated by their pediatricians for suppurative lymphadenitis (seven patients) or retropharyngeal abscess (three patients). KD was finally diagnosed either after antibiotics had been ineffective or when other symptoms characteristic of KD emerged. Conclusion Low-density lesions in the retropharyngeal space were identified by CECT in 3.6% of the KD patients. Early diagnosis of KD is essential because coronary artery lesions develop in 50% of untreated patients. If a child presents with fever, cervical lymphadenopathy, and swelling of the retropharyngeal space, KD should be included in the differential diagnoses.