Osteosarcoma risk after simultaneous incorporation of the long-lived radionuclide super(227)Ac and the short-lived radionuclide super(227)Th

The effect of injection of 1.85 kBq/kg of the long-lived radionuclide super(227)Ac on the induction of osteosarcomas in female NMRI mice by different dose levels (18.5, 74, and 185 kBq/kg) of the short-lived radionuclide super(227)Th was investigated. The highest absolute osteosarcoma incidence was...

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Bibliographic Details
Published in:Radiation research 1990-01, Vol.121 (1), p.14-20
Main Authors: Mueller, WA, Murray, AB, Linzner, U, Luz, DA
Format: Article
Language:English
Online Access:Get full text
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Summary:The effect of injection of 1.85 kBq/kg of the long-lived radionuclide super(227)Ac on the induction of osteosarcomas in female NMRI mice by different dose levels (18.5, 74, and 185 kBq/kg) of the short-lived radionuclide super(227)Th was investigated. The highest absolute osteosarcoma incidence was observed with the highest doses of super(227)Th. Addition of super(227)Ac resulted in an additional osteosarcoma incidence only at the lowest dose of super(227)Th and did not affect the osteosarcoma incidence resulting from higher doses of super(227)Th. The longest times to tumor appearance were observed with super(227)Ac alone. The latent period in two different age groups (4 weeks and 10-12 weeks) appeared to be similar following injection with combined doses of super(227)Ac but different after injection of each radionuclide alone.
ISSN:0033-7587