Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats

Endrin depletes glutathione levels and induces lipid peroxidation in various species of animals. We have, therefore, examined the effect of antioxidants on these parameters in endrin-treated rats. Butylated hydroxyanisole (BHA), vitamin E, vitamin C, and the glutathione precursor cysteine significan...

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Bibliographic Details
Published in:Archives of environmental contamination and toxicology 1990-05, Vol.19 (3), p.302-306
Main Authors: Numan, I.T. (University of Baghdad, Baghdad, Iraq), Hassan, M.Q, Stohs, S.J
Format: Article
Language:English
Subjects:
Animals
ANTIOXIDANTES
ANTIOXIDANTS
Antioxidants - pharmacology
ANTIOXYDANT
Endrin - antagonists & inhibitors
Endrin - toxicity
Female
Glutathione - physiology
Lipid Peroxidation - drug effects
LIPIDE
LIPIDOS
LIPIDS
OXIDACION
OXIDATION
OXYDATION
PEPTIDE
PEPTIDES
PEPTIDOS
PESTICIDE
PESTICIDES
PLAGUICIDAS
PROTECCION
PROTECTION
RAT
RATA
RATS
Rats, Inbred Strains
TOXICIDAD
TOXICITE
TOXICITY
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Summary:Endrin depletes glutathione levels and induces lipid peroxidation in various species of animals. We have, therefore, examined the effect of antioxidants on these parameters in endrin-treated rats. Butylated hydroxyanisole (BHA), vitamin E, vitamin C, and the glutathione precursor cysteine significantly inhibited hepatic glutathione depletion and lipid peroxidation induced by 4 mg endrin/kg body weight. Furthermore, these antioxidants provided partial protection against lethality produced by 8 mg endrin/kg body weight. These results suggest but do not prove that free radical-mediated lipid peroxidation and glutathione depletion may be involved in the toxic manifestations of endrin.
ISSN:0090-4341
1432-0703
DOI:10.1007/BF01054969