An exploratory split-face study of a dual-wavelength laser system on erythromelanosis follicularis faciei in Chinese population

• Published in: Journal of the European Academy of Dermatology and Venereology 2014-10, Vol.28 (10), p.1286-1291
• Main Authors: Wang, B., Wu, Y., Zhu, X., Xu, X.-G., Chen, H.-D., Li, Y.-H.
• Format: Article
• Language: English
• Subjects: Adult; Asian Continental Ancestry Group - ethnology; China - epidemiology; Double-Blind Method; Erythema - ethnology; Erythema - pathology; Erythema - surgery; Facial Dermatoses - ethnology; Facial Dermatoses - pathology; Facial Dermatoses - surgery; Female; Follow-Up Studies; Humans; Incidence; Laser Therapy; Lasers, Dye - therapeutic use; Lasers, Solid-State - therapeutic use; Male; Melanosis - ethnology; Melanosis - pathology; Melanosis - surgery; Middle Aged; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1111/jdv.12249

Background Erythromelanosis follicularis faciei (EFF) is clinically characterized by well‐demarcated erythema, hyperpigmentation and follicular papules. No satisfactory therapy has been widely accepted. Objective This study was aimed to evaluate the efficiency and complications of a dual‐wavelength laser system in the treatment of EFF in Chinese population. Methods Twelve Chinese patients with EFF were enrolled in this study. One side of the face was randomized to receive five successions of treatments at intervals of 6–8 weeks, with the other side spared as control. The parameters were set as follows: energy densities of 6.5–7.5 J/cm2 with pulsed dye laser (PDL) and 35–50 J/cm2 with Nd:YAG; pulse duration of 0.5 ms with PDL and 15 ms with Nd:YAG; a delay time of 100 ms between delivery of the two wavelengths. The efficacy was evaluated using subjective assessment and non‐invasive measurement. Results After five sessions of treatment, over 40% patients achieved more than 50% (moderate or significant) improvement. The efficacy maintained at 3‐month follow‐up. The values of erythema index and melanin index on treated side were significantly less than those on untreated side after sessions of treatments. Adverse effects of treated side were limited. Conclusion Using this split‐face module, dual‐wavelength laser system treatment is proved to be suitable for Chinese EFF. Adverse effects were minimal.