Acute lymphoblastic leukemia in a girl with Wilson's disease

Wilson's disease (WD) is an autosomal recessive defect in cellular copper transportation. Although acute lymphoblastic leukemia (ALL) is the most common form of childhood malignancy, only two cases of ALL associated with WD have been reported to date. One patient died of relapse and infection,...

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Bibliographic Details
Published in:Pediatrics international 2014-08, Vol.56 (4), p.626-629
Main Authors: Maeda, Sayaka, Matsubara, Hiroshi, Hiejima, Eitaro, Tanaka, Atsushi, Okada, Masayuki, Kato, Itaru, Umeda, Katsutsugu, Hiramatsu, Hidefumi, Watanabe, Ken‐ichiro, Heike, Toshio, Adachi, Souichi
Format: Article
Language:English
Subjects:
ATP7B
Chemotherapy
Child
Copper
d‐penicillamine
Female
Genetic disorders
glutathione‐S‐transferase
Hepatolenticular Degeneration - complications
Humans
Leukemia
liver toxicity
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
zinc acetate
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Summary:Wilson's disease (WD) is an autosomal recessive defect in cellular copper transportation. Although acute lymphoblastic leukemia (ALL) is the most common form of childhood malignancy, only two cases of ALL associated with WD have been reported to date. One patient died of relapse and infection, and the other died of neutropenic sepsis during the treatment. We here describe the case of a 10‐year‐old girl with WD and ALL. Adverse events of chemotherapy, including liver toxicity and severe myelosuppression, necessitated adjustments in the chemotherapy doses. After completion of the treatment, the patient has remained in remission from ALL without progression of liver damage for 2 years. Severe treatment‐related toxicity should be considered in chemotherapy for patients with WD.
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.12313