Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: A systems neuroscience perspective

Resting-state functional magnetic resonance imaging (RFMRI) enables researchers to monitor fluctuations in the spontaneous brain activities of thousands of regions in the human brain simultaneously, representing a popular tool for macro-scale functional connectomics to characterize normal brain func...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2014-09, Vol.45, p.100-118
Main Authors: ZUO, Xi-Nian, XING, Xiu-Xia
Format: Article
Language:English
Subjects:
Behavioral psychophysiology
Biological and medical sciences
Brain - physiology
Connectome - methods
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging - methods
Neural Pathways - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reproducibility of Results
Signal Processing, Computer-Assisted
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Summary:Resting-state functional magnetic resonance imaging (RFMRI) enables researchers to monitor fluctuations in the spontaneous brain activities of thousands of regions in the human brain simultaneously, representing a popular tool for macro-scale functional connectomics to characterize normal brain function, mind-brain associations, and the various disorders. However, the test-retest reliability of RFMRI remains largely unknown. We review previously published papers on the test-retest reliability of voxel-wise metrics and conduct a meta-summary reliability analysis of seven common brain networks. This analysis revealed that the heteromodal associative (default, control, and attention) networks were mostly reliable across the seven networks. Regarding examined metrics, independent component analysis with dual regression, local functional homogeneity and functional homotopic connectivity were the three mostly reliable RFMRI metrics. These observations can guide the use of reliable metrics and further improvement of test-retest reliability for other metics in functional connectomics. We discuss the main issues with low reliability related to sub-optimal design and the choice of data processing options. Future research should use large-sample test-retest data to rectify both the within-subject and between-subject variability of RFMRI measurements and accelerate the application of functional connectomics.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2014.05.009