Crossed Cerebellar Diaschisis Detected by Arterial Spin-Labeled Perfusion Magnetic Resonance Imaging in Subacute Ischemic Stroke

Background Crossed cerebellar diaschisis (CCD) was a common radiological phenomenon manifested as reduced blood flow and metabolism in the cerebellar hemisphere contralateral to a supratentorial cerebral lesion. The hypoperfusion and hypometabolism in the contralateral cerebellum in CCD was traditio...

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Published in:Journal of stroke and cerebrovascular diseases 2014-10, Vol.23 (9), p.2378-2383
Main Authors: Chen, Shuai, MD, Guan, Min, MD, Lian, Hao-Jun, MD, Ma, Li-Jia, MD, Shang, Jun-Kui, MD, He, Shuang, MD, Ma, Ming-Ming, MD, Zhang, Mi-Lan, MD, Li, Zi-Yuan, MD, Wang, Mei-Yun, MD, PhD, Shi, Da-Peng, MD, Zhang, Jie-Wen, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
arterial spin-labeling
Brain Ischemia - complications
Brain Ischemia - pathology
Cardiovascular
Cerebellar Diseases - etiology
Cerebellar Diseases - pathology
Cerebellum - pathology
Cerebrovascular Circulation
Crossed cerebellar diaschisis
Female
Humans
Image Processing, Computer-Assisted
magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neurology
Prospective Studies
Spin Labels
stroke
Stroke - complications
Stroke - pathology
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Summary:Background Crossed cerebellar diaschisis (CCD) was a common radiological phenomenon manifested as reduced blood flow and metabolism in the cerebellar hemisphere contralateral to a supratentorial cerebral lesion. The hypoperfusion and hypometabolism in the contralateral cerebellum in CCD was traditionally detected by positron emission tomography (PET) and single-photon emission computed tomography (SPECT). The present prospective study aimed to assess the detection of CCD in subacute stage ischemic stroke by arterial spin-labeling (ASL) perfusion technique with a 3.0-T magnetic resonance imaging (MRI) scanner. Methods ASL images were obtained from 46 patients with supratentorial ischemic stroke at subacute stage. Regional cerebral blood flow values in the cerebellar hemispheres were measured on a region of interest basis. Results Twenty-four of 46 (52%) patients showed CCD phenomenon by ASL-MRI method, which was in line with the PET/SPECT series. Infarctions in basal ganglia areas are prone to cause CCD. Conclusions With advantages in easy acquisition and no radiation, ASL-MRI seems to be an ideal tool for the detection and follow-up of CCD.
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2014.05.009