The cyclooxygenase-2/thromboxane A2 pathway: a bridge from rheumatoid arthritis to lung cancer?

Highlights • Molecular mechanism is still unknown for LC development in RA patients. • The COX-2/TxA2 pathway can be induced in tumour and synovial tissue. • A positive feedback loop for the COX-2/TxA2 pathway promotes LC growth. • Such a feedback loop may also exist in RA-FLS. • Targeting COX-2-der...

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Bibliographic Details
Published in:Cancer letters 2014-11, Vol.354 (1), p.28-32
Main Authors: Huang, Qing-Chun, Huang, Run-Yue
Format: Article
Language:English
Subjects:
Aqueous solutions
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - metabolism
Auto-regulatory feedback loop
Biosynthesis
Cancer therapies
Confidence intervals
Cyclooxygenase 2 - metabolism
Cyclooxygenase-2
Drug therapy
Fibroblasts - metabolism
Gene Expression Profiling
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Humans
Inflammation
Lung cancer
Lung Neoplasms - complications
Lung Neoplasms - metabolism
Rheumatoid arthritis
Rodents
Skin cancer
Smoking
Studies
Synovial Fluid - metabolism
Thromboxane A2
Thromboxane A2 - metabolism
Transcription factors
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Summary:Highlights • Molecular mechanism is still unknown for LC development in RA patients. • The COX-2/TxA2 pathway can be induced in tumour and synovial tissue. • A positive feedback loop for the COX-2/TxA2 pathway promotes LC growth. • Such a feedback loop may also exist in RA-FLS. • Targeting COX-2-derived TxA2 may block LC development in RA patients.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.08.024