The effect of fractionated radiotherapy in sensorineural hearing loss: An animal model

Objectives/Hypothesis The purpose of this study is to assess the effect of fractionated radiotherapy on sensorineural hearing loss using an animal model. Study Design In vivo animal study. Methods Ears of 25 guinea pigs were divided into three groups: control, irradiated with a total of 48 gray (Gy)...

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Bibliographic Details
Published in:The Laryngoscope 2014-10, Vol.124 (10), p.E418-E424
Main Authors: Mujica-Mota, Mario A., Ibrahim, Farid F., Bezdjian, Aren, Devic, Slobodan, Daniel, Sam J.
Format: Article
Language:English
Subjects:
ABR
Animals
Audiometry, Pure-Tone
Cochlea - diagnostic imaging
Cochlea - pathology
Disease Models, Animal
Dose Fractionation
Dose-Response Relationship, Radiation
DPOAE
Ears & hearing
Evoked Potentials, Auditory, Brain Stem
Female
guinea pig
Guinea Pigs
Hearing - physiology
Hearing aids
Hearing loss
Hearing Loss, Sensorineural - pathology
Hearing Loss, Sensorineural - physiopathology
Hearing Loss, Sensorineural - radiotherapy
Otoacoustic Emissions, Spontaneous
Radiation therapy
Radiography
Radiotherapy
sensorineural hearing loss
Treatment Outcome
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Summary:Objectives/Hypothesis The purpose of this study is to assess the effect of fractionated radiotherapy on sensorineural hearing loss using an animal model. Study Design In vivo animal study. Methods Ears of 25 guinea pigs were divided into three groups: control, irradiated with a total of 48 gray (Gy), and 71 Gy. Unilateral exposure of 48 Gy and 71 Gy fractionated irradiation was given for a 4‐week period. Auditory brainstem response and distortion products otoacoustic emissions (DPOAE) were tested prior to irradiation and 1, 6, 10, and 16 weeks after completion of radiotherapy to assess the hearing threshold shift postradiotherapy over time. Results No significant differences in hearing thresholds between the low dose radiation (48 Gy) and the control group (no radiation) underlined that 48 Gy caused no hearing deficits (P = 0.37). The higher dose (71 Gy) showed progressive deterioration of the hearing function over time. Three‐way ANOVA interactions revealed significant group‐time effects (F= 9.261; P 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24756