Phylogeographic analysis on the travel-related introduction of HIV-1 non-B subtypes to Northern Poland

Phylodynamic, sequence data based reconstructions for the surveillance of the geographic spatial spread are a powerful tool in molecular epidemiology. In this study region of origin for the set of 57 partial pol sequences derived from the patients the history of travel-related HIV transmission was a...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2014-10, Vol.27, p.121-130
Main Authors: Parczewski, Milosz, Urbanska, Anna, Grzeszczuk, Anna, Maciejewska, Katarzyna, Witak-Jedra, Magdalena, Leszczyszyn-Pynka, Magdalena
Format: Article
Language:English
Subjects:
Adult
Female
Genetic Variation
Genotype
Geography
HIV Infections - epidemiology
HIV Infections - transmission
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
Humans
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Phylogeography
Poland - epidemiology
Risk Factors
Travel
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Summary:Phylodynamic, sequence data based reconstructions for the surveillance of the geographic spatial spread are a powerful tool in molecular epidemiology. In this study region of origin for the set of 57 partial pol sequences derived from the patients the history of travel-related HIV transmission was analyzed using phylogeographic approach. Maximum likelihood trees based on the sets of country-annotated reference sequences were inferred for identified non-B variants. Region of sequence import was assigned using on the highest approximate likelihood ratios. Import of the A1 clades was traced to the Eastern Europe and associated with immigration from this region. Subtype C infections clustered most frequently with sequences of the South African origin while majority of subtype Ds were similar to the European clades. Subtype G sequences clustered with Portuguese lineage, CRF01_AE with Eastern or South-Eastern Asian. Eastern European, Middle African or Western African lineage was assigned for the CFR02_AG. Rare circulating recombinants originated either from Central Africa (CRF11_cpx - Democratic Republic of Congo, CRF13_cpx - Central African Republic, CRF37_cpx - Cameroon) or South America (CRF28_BF and CRF46_BF - Brazil). Import of the HIV-1 non-B variants, including recombinant forms previously rarely found in Poland and Europe is frequent among travelers. Observed founder events result in the heterosexually-driven introduction of the novel HIV-1 variants into the population.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2014.07.004