Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice

The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the mus...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2010-10, Vol.73 (10), p.1708-1710
Main Authors: Mukai, Rie, Nakao, Reiko, Yamamoto, Hironori, Nikawa, Takeshi, Takeda, Eiji, Terao, Junji
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Animals
Antioxidants - pharmacology
Biological and medical sciences
Flavones - chemistry
Flavones - pharmacology
Hindlimb Suspension
Lipid Peroxidation - drug effects
Male
Medical sciences
Mice
Mice, Inbred C57BL
Molecular Structure
Muscle
Muscle, Skeletal - drug effects
Muscular Atrophy - drug therapy
Pharmacology. Drug treatments
Polymerase Chain Reaction
Propane - analogs & derivatives
Propane - pharmacology
Quercetin - chemistry
Quercetin - pharmacology
Thiobarbituric Acid Reactive Substances - analysis
Ubiquitin-Protein Ligases - drug effects
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Summary:The effects of quercetin (1) were investigated on disused muscle atrophy using mice that underwent tail suspension. Periodic injection of 1 into the gastrocnemius muscle suppressed muscle weight loss and ubiquitin ligase expression. Compound 1 reduced the enhancement of lipid peroxidation in the muscle. Injection of N-acetyl-l-cysteine, but not flavone (2), also prevented muscle weight loss and enhancement of lipid peroxidation. These findings demonstrate that 1 can prevent disused muscle atrophy by attenuating the expression of ubiquitin ligases and that such prevention originates from its antioxidant activity.
ISSN:0163-3864
1520-6025
DOI:10.1021/np100240y