Transforming growth factor-β1-induced epithelial–mesenchymal transition generates ALDH-positive cells with stem cell properties in cholangiocarcinoma

Highlights • TGF-β1-induced EMT promotes cancer stem cell-like properties. • ALDH acts as a marker for cancer stem cells in cholangiocarcinoma. • The expressions of TGF-β1 and ALDH1 can predict the prognosis of cholangiocarcinoma.

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Bibliographic Details
Published in:Cancer letters 2014-11, Vol.354 (2), p.320-328
Main Authors: Shuang, Ze-Yu, Wu, Wen-Chao, Xu, Jing, Lin, Guohe, Liu, Yong-Cheng, Lao, Xiang-Ming, Zheng, Limin, Li, Shengping
Format: Article
Language:English
Subjects:
Aldehyde dehydrogenase
Aldehyde Dehydrogenase - metabolism
Animals
Bile Duct Neoplasms - enzymology
Bile Duct Neoplasms - pathology
Bile Ducts, Intrahepatic - drug effects
Bile Ducts, Intrahepatic - enzymology
Bile Ducts, Intrahepatic - pathology
Cancer stem cells
Cell Line, Tumor
Cholangiocarcinoma
Cholangiocarcinoma - enzymology
Cholangiocarcinoma - pathology
Epithelial-Mesenchymal Transition - drug effects
Epithelial–mesenchymal transition
Hematology, Oncology and Palliative Medicine
Humans
Male
Mice
Mice, Inbred NOD
Mice, SCID
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - enzymology
Neoplastic Stem Cells - pathology
Transforming Growth Factor beta1 - pharmacology
Transforming growth factor-β1
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Description
Summary:Highlights • TGF-β1-induced EMT promotes cancer stem cell-like properties. • ALDH acts as a marker for cancer stem cells in cholangiocarcinoma. • The expressions of TGF-β1 and ALDH1 can predict the prognosis of cholangiocarcinoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.08.030