Taenia solium tapeworms synthesize corticosteroids and sex steroids in vitro

Highlights • Tapeworms synthesize testosterone from tritiated progesterone. • Tapeworms increase testosterone synthesis if androstenedione was offered as the precursor. • The parasites synthesize corticosteroids from3 H-progesterone. • Deoxycorticosterone and deoxycortisol were the main corticostero...

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Bibliographic Details
Published in:General and comparative endocrinology 2014-09, Vol.205, p.62-67
Main Authors: Valdez, R.A, Jiménez, P, Fernández Presas, A.M, Aguilar, L, Willms, K, Romano, M.C
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - biosynthesis
Androstenedione - biosynthesis
Animals
Chromatography, Thin Layer
Corticosteroid synthesis
Cricetinae
Endocrinology & Metabolism
Gonadal Steroid Hormones - biosynthesis
Helmynths
Humans
Parasites
Progesterone - metabolism
Sex steroid synthesis
Taenia solium - metabolism
Taenia solium tapeworms
Taeniids
Testosterone - biosynthesis
Tritium - metabolism
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Summary:Highlights • Tapeworms synthesize testosterone from tritiated progesterone. • Tapeworms increase testosterone synthesis if androstenedione was offered as the precursor. • The parasites synthesize corticosteroids from3 H-progesterone. • Deoxycorticosterone and deoxycortisol were the main corticosteroids produced by the tapeworms.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2014.04.014