Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury

• Published in: Respiratory physiology & neurobiology 2014-11, Vol.203, p.45-50
• Main Authors: Cavalcanti, Vinícius, Santos, Cintia Lourenço, Samary, Cynthia Santos, Araújo, Mariana Neves, Heil, Luciana Boavista Barros, Morales, Marcelo Marcos, Silva, Pedro Leme, Pelosi, Paolo, Fernandes, Fatima Carneiro, Villela, Nivaldo, Rocco, Patricia Rieken Macedo
• Format: Article
• Language: English
• Subjects: Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Animals; Arterial blood gases; Cytokines; Cytokines - blood; Cytokines - genetics; Dexmedetomidine - therapeutic use; Disease Models, Animal; Endotoxins - toxicity; Female; Histology; Hypnotics and Sedatives - therapeutic use; Inflammation; Lipopolysaccharides - toxicity; Lung - pathology; Lung mechanics; Medical Education; NF-E2 Transcription Factor - blood; NF-E2 Transcription Factor - genetics; Nitric Oxide Synthase - blood; Nitric Oxide Synthase - genetics; Propofol - therapeutic use; Pulmonary/Respiratory; Rats; Rats, Wistar; RNA, Messenger - metabolism; Statistics, Nonparametric; Thiopental - therapeutic use
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2014.08.008

Highlights • Short-term intravenous administration of dexmedetomidine and propofol led to different functional effects and activation of biological markers in endotoxin-induced mild acute lung injury. • Propofol reduced static lung elastance, resistive pressure, alveolar collapse and lower IL (interleukin)-6 and IL-1β expression compared to dexmedetomidine. • Dexmedetomidine did not modify lung mechanics and histology, but improved oxygenation and decreased inducible nitric oxide and increased nuclear factor erythroid 2-related factor 2 expression in lung tissue.